First you need development libraries: $ sudo apt-get install libsqlite3-dev Then you have to download pysqlite files from http://code.google.com/p/pysqlite/ Next steps are usual: unpack and change dir After that run (you should have gcc - GNU C compiler - of course): $ python setup.py build After compilation runs successfully you are able to install pysqlite with: $ sudo python setup.py install That's all